Anti-sycotic efficacy of Thuja Occidentalis in chronic recurrent urinary tract infections: A randomized double-blind placebo-controlled clinical trial with symptom assessment, recurrence prevention, and biomarker analysis

Abstract

Background: Chronic recurrent urinary tract infections (CRUTIs) are persistent conditions significantly affecting patients' quality of life. Conventional treatments often face challenges such as antimicrobial resistance, recurrence, and adverse effects. Thuja Occidentalis, a homeopathic remedy, is traditionally recognized for its anti-sycotic properties and immunomodulatory effects.

Objective: This study evaluates the anti-sycotic efficacy of Thuja Occidentalis in managing CRUTIs through symptom assessment, recurrence prevention, and biomarker analysis.

Methods: A randomized double-blind placebo-controlled trial was conducted on 200 participants diagnosed with CRUTIs. Participants were randomly assigned to the Thuja Occidentalis group (Group A) or placebo group (Group B). Symptom severity, recurrence rates, and urinary biomarkers (e.g., leukocyte count, bacterial load) were assessed over 12 weeks, with a 3-month follow-up period.

Results: Group A showed a significant reduction in symptom severity scores (P=0.038) and urinary leukocyte counts (P=0.042) compared to Group B. Recurrence rates were notably lower in Group A (11%) than in Group B (23%), (P=0.027). Adverse effects were minimal in both groups.

Conclusion: Thuja Occidentalis demonstrated significant efficacy in reducing symptoms, preventing recurrence, and modulating biomarkers in patients with CRUTIs. It presents a promising adjunct or alternative to conventional therapies.